HRID48689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61147

Acetyl bromide, 2-bromo-

C2H2Br2O

HCID2733933

(R)-1-Aminoindane

C9H11N

结构：COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC

HCID22742720

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CC2c3cc(OC(C)C)c(OC)cc3CCN2CC(=O)N[C@@H]2CCc3ccccc32)cc1OC

HCID69894203

未命名化合物

PROCEDURE

实验过程

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R)-1-amino-indane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1bc22ff6864647f2809ba8c17961d6b3
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06703392B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][NH:8]1.Br[CH2:29][C:30](Br)=[O:31].[NH2:33][C@H:34]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36][CH2:35]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][N:8]1[CH2:29][C:30]([NH:33][C@H:34]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36][CH2:35]1)=[O:31]