Bromoacetyl bromide → 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide

HRID 48698Notes

Reaction equation

HRID 48698 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][NH:8]1.Br[CH2:29][C:30](Br)=[O:31].[CH3:33][CH:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:37]([NH2:44])[CH2:36][CH2:35]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][N:8]1[CH2:29][C:30]([NH:44][CH:37]1[C:38]2[C:43](=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:34]([CH3:33])[CH2:35][CH2:36]1)=[O:31]

Participants

4

Reactant 3

HCID 61147Bromoacetyl bromideHCID 227425554-Methyl-1,2,3,4-tetrahydronaphthalen-1-amineHCID 227427201-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 227427522-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide

Procedure

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methyl-1,2,3,4-tetrahydro-1-naphthylamine

Sources & evidence

ORD record
ord-527dbed6d2ad4fa3b23a87f13b87414b
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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