Hydrochloric Acid → HCID 19096824, compound

HRID 486988Notes

Reaction equation

HRID 486988 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:18])[C:10]([Br:17])([CH3:16])[C:11]([O:13]CC)=[O:12])=[C:4]([CH3:19])[CH:3]=1.O.[OH-].[K+].[K].Cl>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:18])[C:10]([Br:17])([CH3:16])[C:11]([OH:13])=[O:12])=[C:4]([CH3:19])[CH:3]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 19096809HCID 19096809, compound2×

Product 1

HCID 19096824HCID 19096824, compound

Procedure

A 1.25 gram (0.003 mole) portion of ethyl 3-[(4-bromo-2-methylphenyl)amino]-2-bromo-2-methyl-3-oxopropanoate prepared in Example XV (Compound 144) was hydrolyzed with water (0.06 gram, 0.003 mole) and ethanolic potassium hydroxide (0.21 gram, 0.003 mole). The potassium salt of the acid was then acidified with concentrated HCl and worked up in a manner similar to that described in Example VII to give 1.04 grams (0.003 mole) of 3-[(4-bromo-2-methylphenyl)amino]-2-bromo-2-methyl-3-oxopropanoic acid as a white solid having a melting point of 133° C.-136° C. NMR analysis of the product indicated the following:

Sources & evidence

ORD record
ord-f85a6de2e4804413b626dbb1d987bc18
Source dataset
uspto-grants-1994_03
Patent number
US05292937

Reaction notes

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