Dicyclohexylcarbodiimide → HCID 19096844, compound

HRID 487024Notes

Reaction equation

HRID 487024 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH:10]([NH:12][CH:13]([C:19]([O-])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:11].C1(N=C=NC2CCCCC2)CCCCC1>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:19](=[O:20])[CH:13]([NH:12][CH:10]=[O:11])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH3:9])[CH:3]=1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 114234-Bromo-2-methylanilineHCID 85670808HCID 85670808, compound

Product 1

HCID 19096844HCID 19096844, compoundYield 18.8%

Procedure

4-Bromo-2-methylaniline (1.48 grams, 0.008 mole), mono-ethyl formamidomalonate (1.39 grams, 0.008 mole), prepared in Part A of this Example, and 1,3-dicyclohexylcarbodiimide (1.64 grams, 0.008 mole) were reacted in a manner similar to that described in Example LVII to give 0.53 gram (0.0015 mole) of ethyl 3-[(4-bromo-2-methylphenyl)amino]-2-formamido-3-oxopropanoate as white crystals having a melting point of 174.5° C.-176° C. Elemental analysis of the product indicated the following:

Workup

  1. customwere reacted in a manner similar to

Sources & evidence

ORD record
ord-6e2f007ac4bc454a8a8ab281e48f407a
Source dataset
uspto-grants-1994_03
Patent number
US05292937

Reaction notes

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