Dicyclohexylcarbodiimide → HCID 19096844, compound

Participants

Reaction Steps

4-Bromo-2-methylaniline (1.48 grams, 0.008 mole), mono-ethyl formamidomalonate (1.39 grams, 0.008 mole), prepared in Part A of this Example, and 1,3-dicyclohexylcarbodiimide (1.64 grams, 0.008 mole) were reacted in a manner similar to that described in Example LVII to give 0.53 gram (0.0015 mole) of ethyl 3-[(4-bromo-2-methylphenyl)amino]-2-formamido-3-oxopropanoate as white crystals having a melting point of 174.5° C.-176° C. Elemental analysis of the product indicated the following:

Provenance & Evidence