HCID 178476976, compound → HCID 178514396, compound

Participants

Reaction Steps

A solution of 0.92 g (2.56 mmol) of tetraethyl 4-((bis(1,1-dimethylethoxycarbonyl)aminoiminomethyl)amino)butane-1,1-bisphosphonate in 15 ml of concentrated hydrochloric acid is heated at boiling point for 12 hours. After concentration, the residue is treated with ethanol. The precipitate is filtered off with suction under reduced pressure and dried under reduced pressure. It is recrystallized from ethanol/water.

Provenance & Evidence