反应详情

A solution of 0.92 g (2.56 mmol) of tetraethyl 4-((bis(1,1-dimethylethoxycarbonyl)aminoiminomethyl)amino)butane-1,1-bisphosphonate in 15 ml of concentrated hydrochloric acid is heated at boiling point for 12 hours. After concentration, the residue is treated with ethanol. The precipitate is filtered off with suction under reduced pressure and dried under reduced pressure. It is recrystallized from ethanol/water.

1. customfor 12 hours
2. concentrationAfter concentration
3. additionthe residue is treated with ethanol
4. filtrationThe precipitate is filtered off with suction under reduced pressure
5. customdried under reduced pressure
6. customIt is recrystallized from ethanol/water