HCID 178476976, compound → HCID 178514396, compound

HRID 487051Notes

Reaction equation

HRID 487051 reaction equation
CC(C)(OC([N:7]([N:15]=[CH:16][NH:17][CH2:18][CH2:19][CH2:20][CH:21]([P:30]([O:35]CC)(=[O:34])[O:31]CC)[P:22]([O:27]CC)(=[O:26])[O:23]CC)C(OC(C)(C)C)=O)=O)C>Cl>[NH2:7][N:15]=[CH:16][NH:17][CH2:18][CH2:19][CH2:20][CH:21]([P:30]([OH:35])(=[O:31])[OH:34])[P:22]([OH:26])(=[O:23])[OH:27]

Participants

3

Reactant 1

HCID 178476976HCID 178476976, compound

Product 1

HCID 178514396HCID 178514396, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 0.92 g (2.56 mmol) of tetraethyl 4-((bis(1,1-dimethylethoxycarbonyl)aminoiminomethyl)amino)butane-1,1-bisphosphonate in 15 ml of concentrated hydrochloric acid is heated at boiling point for 12 hours. After concentration, the residue is treated with ethanol. The precipitate is filtered off with suction under reduced pressure and dried under reduced pressure. It is recrystallized from ethanol/water.

Workup

  1. customfor 12 hours
  2. concentrationAfter concentration
  3. additionthe residue is treated with ethanol
  4. filtrationThe precipitate is filtered off with suction under reduced pressure
  5. customdried under reduced pressure
  6. customIt is recrystallized from ethanol/water

Sources & evidence

ORD record
ord-fa08081f49fb4f699931c2a4d811842e
Source dataset
uspto-grants-1994_03
Patent number
US05294608

Reaction notes

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