反应详情

To a suspension of 2.0 g of impure 2-butyl-6-(bromomethyl)-4(1H)-quinazolinone (Example 3) in 35 ml of dimethylsulfoxide and 20 ml of water is added 1.0 g of potassium carbonate. The reaction mixture is heated at reflux for 6 hours, resulting in a complete solution. Upon cooling slowly to room temperature a white precipitate forms and is collected by filtration. The filter cake is purified by flash chromatography on silica gel, eluting with 9:1 chloroform-methanol to give 0.67 g of the desired product as a white solid.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 6 hours
3. customresulting in a complete solution
4. filtrationis collected by filtration
5. customThe filter cake is purified by flash chromatography on silica gel
6. washeluting with 9:1 chloroform-methanol