Hydroxyamine hydrochloride → HCID 136404506, compound

HRID 487091Notes

Reaction equation

HRID 487091 reaction equation
[C:1]([C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[C:6]([CH2:23][CH3:24])[CH:5]=1)(=O)[CH3:2].Cl.[NH2:26][OH:27].C([O-])(=O)C.[Na+]>CO>[OH:27][N:26]=[C:1]([C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[C:6]([CH2:23][CH3:24])[CH:5]=1)[CH3:2]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 14820108HCID 14820108, compound

Product 1

HCID 136404506HCID 136404506, compoundYield 42.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 7.1 g of 7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylheptanoic acid, 0.149 g of hydroxylamine hydrochloride, 0.176 g of sodium acetate, and 50 ml of methanol were heated at reflux for 48 hours. The reaction mixture was allowed to cool to room temperature and the resulting solid collected by filtration. The solid was crystallized from methylene chloride/ hexane to provide 0.32 g of the desired titled product.

Workup

  1. temperaturewere heated
  2. temperatureat reflux for 48 hours
  3. filtrationthe resulting solid collected by filtration
  4. customThe solid was crystallized from methylene chloride/ hexane

Sources & evidence

ORD record
ord-7fa82f700e4346b18447c0ac0d4030da
Source dataset
uspto-grants-1994_03
Patent number
US05294613

Reaction notes

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