HCID 54421298, compound → HCID 19094155, compound

HRID 487133Notes

Reaction equation

HRID 487133 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[O:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([CH:18]=[CH:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[H][H]>[Pd].C(O)C>[F:31][C:28]1[CH:27]=[CH:26][C:25]([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[O:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14][CH2:13]2)=[CH:30][CH:29]=1

Participants

5

Reactant 2

HCID 54421298HCID 54421298, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19094155HCID 19094155, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.14 g of 10% w/w palladium-on-charcoal and 1.569 g of ethyl 3-{1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidyl}acrylate (prepared as described in Example 1) were added to 30 ml of ethanol, and the mixture was stirred in an atmosphere of hydrogen at room temperature for 30 minutes. At the end of this time, the catalyst was removed by filtration, and the filtrate was freed from the solvent by distillation under reduced pressure, to afford 1.46 g (93% yield) of the title compound as a yellow oil.

Workup

  1. customAt the end of this time, the catalyst was removed by filtration
  2. distillationthe filtrate was freed from the solvent by distillation under reduced pressure

Sources & evidence

ORD record
ord-643b5b3a385b465d8d962aed3ab76cdb
Source dataset
uspto-grants-1994_03
Patent number
US05294623

Reaction notes

Loading…