Hydrochloric Acid → HCID 19390830, compound

HRID 487156Notes

Reaction equation

HRID 487156 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:24]>C(O)C>[ClH:24].[ClH:24].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]3)=[CH:13][CH:12]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19390919HCID 19390919, compound

Product 1

HCID 19390830HCID 19390830, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 100 ml of ethanol was dissolved 4.8 g of the 1-acetyl-4-(4-piperazinobenzoyl)piperidine (Compound No. 2) prepared in Example 4, followed by addition of 3.5 ml of concentrated hydrochloric acid. The reaction mixture was worked up in the same manner as Examples 15 and 17 to give a solid, which was recrystallized from ethanol-ethyl acetate. The procedure was 3.0 g of a hygroscopic colorless solid melting at 136°-137° C.

Workup

  1. customprepared in Example 4
  2. customto give a solid, which
  3. customwas recrystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-f65cefaec4654fe79c7b1fe128b5aa5f
Source dataset
uspto-grants-1994_03
Patent number
US05294625

Reaction notes

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