HCID 19094209, compound → HCID 19094249, compound

HRID 487198Notes

Reaction equation

HRID 487198 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:8]2[C:18]([C:24]([OH:26])=[O:25])=[C:19](Cl)[C:20]([Cl:22])=[CH:21][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].ClC1C=C([N+]([O-])=O)C(NCC2C=CC=CC=2Cl)=C(C=1)C(O)=O>>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[C:8]2[C:18]([C:24]([OH:26])=[O:25])=[CH:19][C:20]([Cl:22])=[CH:21][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 19094209HCID 19094209, compoundHCID 19094238HCID 19094238, compound

Product 1

HCID 19094249HCID 19094249, compoundYield 89.3%

Procedure

The procedure of Example 1(iii and iv) was followed using 5-chloro-2-[(2-chlorophenyl)methyl]amino-3-nitrobenzoic acid (1.50 g, 4.40 mmol) in place of 5-bromo-2-[(2-chlorophenyl)methyl]amino-3-nitrobenzoic acid to give 1.48 g (89.3%) of the title compound, which was recrystallized from methanol; mp 261°-262° C.

Sources & evidence

ORD record
ord-3febf5f307dd489e8711f9727d5bc448
Source dataset
uspto-grants-1994_03
Patent number
US05294631

Reaction notes

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