Hydrogen Bromide → HCID 178523265, compound

HRID 487234Notes

Reaction equation

C[O:2][P:3]([CH2:7][NH:8][C@@H:9]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[NH:19][N:18]=[N:17][N:16]=1)=[O:11])([O:5]C)=[O:4].Br>>[P:3]([CH2:7][NH:8][C@@H:9]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:25][CH:26]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[NH:19][N:18]=[N:17][N:16]=1)=[O:11])([OH:4])([OH:5])=[O:2]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 178502958HCID 178502958, compound

Product 1

HCID 178523265HCID 178523265, compound

Procedure

(S)-5-[N-[2-(Dimethylphosphonomethylamino)-3-(4-biphenylyl)propionyl]-2-aminoethyl]tetrazole is treated with 30% HBr/glacial HOAc under conditions similar to those of example 1 to yield (S)-5-[N-[2-(phosphonomethylamino)-3-(4-biphenylyl)propionyl]-2-aminoethyl]tetrazole.

Sources & evidence

ORD record: ord-3f2211b618434ed2b244e664ac2a731c
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05294632

Reaction notes

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