Ethanol → HCID 19432795, compound

HRID 487255Notes

Reaction equation

HRID 487255 reaction equation
[C:1]([N:5]1[C:9]([NH2:10])=[C:8]([C:11]#[N:12])[C:7]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].C([OH:22])C.[OH-].[K+].OO>O>[C:1]([N:5]1[C:9]([NH2:10])=[C:8]([C:11]([NH2:12])=[O:22])[C:7]([NH:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 4

HCID 702EthanolHCID 784Hydrogen PeroxideHCID 14797Potassium HydroxideHCID 19432825HCID 19432825, compound

Product 1

HCID 19432795HCID 19432795, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-tert-Butyl-3-phenylamino-5-amino-1H-pyrazole-4-carbonitrile (1.0 g, 0.004 mol), 50% aqueous ethanol (30 ml), potassium hydroxide (1.8 g, 0.03 mol) and 30% hydrogen peroxide (2.5 ml, 0.02 mol) were combined and stirred at room temperature for 24 hours, then refluxed on a steam bath for 1 hour. The reaction mixture was added to water, and the obtained solid was filtered and washed with water to afford 0.68 g (64%) of 1-tert-butyl-3-phenylamino-5-amino-1H-pyrazole-4-carboxamide as a gray solid, m.p. 225°-227° C.

Workup

  1. temperaturerefluxed on a steam bath for 1 hour
  2. filtrationthe obtained solid was filtered
  3. washwashed with water

Sources & evidence

ORD record
ord-8fd174315cc44816ba1e3f7638933d21
Source dataset
uspto-grants-1994_03
Patent number
US05294612

Reaction notes

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