Hydrochloric Acid → HCID 19094707, compound

HRID 487344Notes

Reaction equation

HRID 487344 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[N+:17]([O-:19])=[O:18].Cl.O>CC(C)=O>[OH:16][CH:13]1[CH2:12][CH2:11][N:10]([C:8]2[CH:7]=[CH:6][C:5]([N+:17]([O-:19])=[O:18])=[C:4]([CH:9]=2)[CH:3]=[O:2])[CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 19094715HCID 19094715, compound

Product 1

HCID 19094707HCID 19094707, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 4.3 g of 5-(4-hydroxypiperidino)-2-nitrobenzaldehyde dimethylacetal in 40 ml of acetone was added 40 ml of 2N hydrochloric acid. After refluxing for 15 min, the reaction mixture was poured into water, and extracted with ethyl acetate. The extract was washed with water, dried, and evaporated under a reduced pressure to give 3.5 g of 5-(4-hydroxypiperidino)-2-nitrobenzaldehyde.

Workup

  1. temperatureAfter refluxing for 15 min
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. customevaporated under a reduced pressure

Sources & evidence

ORD record
ord-5dd9b1ee45e44409aa9e5f6c10ab2a45
Source dataset
uspto-grants-1994_03
Patent number
US05294718

Reaction notes

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