反应详情

This 7-bromocarbostyril was dissolved in 2.5 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 56 mg of 7-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

1. temperaturemixture was refluxed for 1 hr
2. concentrationThe reaction mixture was concentrated
3. custompurified by a silica gel column chromatography