7-Bromoquinolin-2(1H)-one → 7-Bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril

HRID 487352Notes

Reaction equation

HRID 487352 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.Cl.[CH3:14][OH:15]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:5][CH:14]([OH:15])[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 142210257-Bromoquinolin-2(1H)-oneHCID 21893726Hydrochloride methanol

Product 1

HCID 190947117-Bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril

Procedure

This 7-bromocarbostyril was dissolved in 2.5 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 56 mg of 7-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

Workup

  1. temperaturemixture was refluxed for 1 hr
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by a silica gel column chromatography

Sources & evidence

ORD record
ord-efe565e451a747feb488e4f20cb8516d
Source dataset
uspto-grants-1994_03
Patent number
US05294718

Reaction notes

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