5-Bromo-1,2-dihydroquinolin-2-one → 5-Bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril

HRID 487353Notes

Reaction equation

HRID 487353 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](=[O:12])[NH:7]2.Cl.[CH3:14][OH:15]>>[Br:1][C:2]1[C:11]([N:7]2[CH2:8][CH2:3][CH:14]([OH:15])[CH2:5][CH2:6]2)=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 142210325-Bromo-1,2-dihydroquinolin-2-oneHCID 21893726Hydrochloride methanol

Product 1

HCID 190947145-Bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril

Procedure

The above 5-bromocarbostyril was dissolved in 1 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 24 mg of 5-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

Workup

  1. temperaturemixture was refluxed for 1 hr
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by a silica gel column chromatography

Sources & evidence

ORD record
ord-03548a8929ac444698bca5d918162ee0
Source dataset
uspto-grants-1994_03
Patent number
US05294718

Reaction notes

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