5-Bromo-1,2-dihydroquinolin-2-one → 5-Bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril

Participants

Reaction Steps

The above 5-bromocarbostyril was dissolved in 1 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 24 mg of 5-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

Provenance & Evidence