(S)-4-Glycyl-3-(1-methylpropyl)-2-oxopiperazine-1-acetic acid t-butyl ester hydrochloride → HCID 178445837, compound

HRID 487431Notes

Reaction equation

HRID 487431 reaction equation
[ClH:1].C([O:6][C:7](=[O:24])[CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:18])[CH2:16][NH2:17])[C@@H:11]([CH:19]([CH3:22])[CH2:20][CH3:21])[C:10]1=[O:23])(C)(C)C.Cl.[NH:26]([C:30]1[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][CH:31]=1)[C:27]([NH2:29])=[NH:28]>>[ClH:1].[NH:26]([C:30]1[CH:38]=[CH:37][C:33]([C:34]([NH:17][CH2:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([CH2:8][C:7]([OH:6])=[O:24])[C:10](=[O:23])[C@@H:11]2[CH:19]([CH3:22])[CH2:20][CH3:21])=[O:18])=[O:35])=[CH:32][CH:31]=1)[C:27]([NH2:29])=[NH:28]

Participants

3

Reactant 2

HCID 70046267(S)-4-Glycyl-3-(1-methylpropyl)-2-oxopiperazine-1-acetic acid t-butyl ester hydrochlorideHCID 178479383HCID 178479383, compound

Product 1

HCID 178445837HCID 178445837, compound

Procedure

(S)-4-Glycyl-3-(1-methylpropyl)-2-oxopiperazine-1-acetic acid t-butyl ester hydrochloride obtained in Working Example 64 (364 mg) and 215 mg of 4-guanidino benzoic acid hydrochloride were subjected to substantially the same procedure as in Working Example 39 to afford 190 mg of the title compound as colorless powder.

Sources & evidence

ORD record
ord-419a1e360fa3485d949b0cd687b783a6
Source dataset
uspto-grants-1994_03
Patent number
US05294713

Reaction notes

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