Potassium Hydroxide → 2-(Thiophen-3-yl)propanoic acid

HRID 487534Notes

Reaction equation

HRID 487534 reaction equation
C[O:2][C:3](=[O:11])[CH:4]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH3:5].[OH-].[K+]>O.C(O)C>[S:8]1[CH:9]=[CH:10][C:6]([CH:4]([CH3:5])[C:3]([OH:11])=[O:2])=[CH:7]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 15327110Methyl 2-(thiophen-3-yl)propanoate

Product 1

HCID 131348672-(Thiophen-3-yl)propanoic acidYield 93.8%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

2-(3-thienyl)propionic acid methyl ester (26.6 g) was added to a water:ethanol (1:4) solution of potassium hydroxide, followed by one-hour refluxing. The reaction was carried out in a similar manner to the foregoing Example 8 to obtain 22.9 g 2-(3-thienyl) propionic acid nD20 1.5361.

Workup

  1. waitfollowed by one-hour
  2. temperaturerefluxing

Sources & evidence

ORD record
ord-565eba5d7296485f8347a3f3e85a639c
Source dataset
uspto-grants-1994_03
Patent number
US05296454

Reaction notes

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