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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 487534Generated: October 26, 2026

Potassium Hydroxide → 2-(Thiophen-3-yl)propanoic acid

https://huagongshe.com/reaction/487534

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
ReactantMethyl 2-(thiophen-3-yl)propanoateHCID 15327110—
SolventWater ethanolHCID 19096565—
Product2-(Thiophen-3-yl)propanoic acidHCID 1313486793.8%

Reaction Steps

2-(3-thienyl)propionic acid methyl ester (26.6 g) was added to a water:ethanol (1:4) solution of potassium hydroxide, followed by one-hour refluxing. The reaction was carried out in a similar manner to the foregoing Example 8 to obtain 22.9 g 2-(3-thienyl) propionic acid nD20 1.5361.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05296454
Source datasetuspto-grants-1994_03
ORD IDord-565eba5d7296485f8347a3f3e85a639c
Source noteuspto-grants-1994_03