Thionyl Chloride → 2-(3-Thienyl)propionic acid chloride

HRID 487535Notes

Reaction equation

HRID 487535 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]([CH3:10])[C:7](O)=[O:8])=[CH:2]1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([CH:6]([CH3:10])[C:7]([Cl:13])=[O:8])=[CH:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 131348672-(Thiophen-3-yl)propanoic acid

Product 1

HCID 218341522-(3-Thienyl)propionic acid chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The 2-(3-thienyl)propionic acid (22.9 g) was dissolved in chloroform (60 ml), to which was added thionyl chloride (20 g), followed by 30 minutes refluxing. The reaction was carried out in a similar manner to the foregoing Example 9 to obtain 2-(3-thienyl)propionic acid chloride with bp 76°-78° C./2.0 torr.

Workup

  1. temperaturerefluxing

Sources & evidence

ORD record
ord-38c575b82ab44d9ab1beab35d1ac6ef0
Source dataset
uspto-grants-1994_03
Patent number
US05296454

Reaction notes

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