HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → 1,3-dihydro-2-oxo-1-(4-morpholinyl)-3-(4-pyridinyl methyl)-2H-indol-3-acetic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1,3-dihydro-1-(4-morpholinyl)-3-(4-pyridinylmethyl)-2H-indol-2-one | HCID 23353976 | — |
| Solvent | Chloroform hexane | HCID 21585165 | — |
| Product | 1,3-dihydro-2-oxo-1-(4-morpholinyl)-3-(4-pyridinyl methyl)-2H-indol-3-acetic acid, ethyl ester | HCID 86747675 | — |
Reaction Steps
The product obtained from Example 20 could be reacted with sodium hydride and ethyl bromoacetate in a manner similar to Example 8 to render the product as a crystalline white solid, m.p. 168°-2/3° C. (hexane-chloroform). High Res. Mass Spec. Calcd. for C22H25N3O4 : 396.1923 (M+H). Found: 396.1922.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05296478 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-891c956dace045559713b28c82405d62 |
| Source note | uspto-grants-1994_03 |