4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine → 4-(4-Fluorophenyl)-1-[1-(4-nitrophenyl)-4-piperidinyl]-1,2,5,6-tetrahydropyridine

HRID 487574Notes

Reaction equation

HRID 487574 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH:25]=2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH2:29][CH2:28][N:27]([CH:13]3[CH2:14][CH2:15][N:10]([C:7]4[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=4)[CH2:11][CH2:12]3)[CH2:26][CH:25]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 1977484-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridineHCID 38425621-(4-Nitrophenyl)piperidin-4-one

Product 1

HCID 190922724-(4-Fluorophenyl)-1-[1-(4-nitrophenyl)-4-piperidinyl]-1,2,5,6-tetrahydropyridine

Procedure

5.5 g of 1-(4-nitrophenyl)-4-piperidone and 4.4 g of 4-(4-fluorophenyl)-1,2,5,6-tetrahydropyridine were reacted as in Example 1. The product crystallized as fumarate.

Workup

  1. customThe product crystallized as fumarate

Sources & evidence

ORD record
ord-ecfc00dc6c264b1a84ff89904ceef1b1
Source dataset
uspto-grants-1994_03
Patent number
US05296485

Reaction notes

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