HCID 19092277, compound → HCID 19092270, compound

HRID 487576Notes

Reaction equation

HRID 487576 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:21][CH2:20][CH:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:17][CH2:18][CH:19]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:20][CH2:21]3)[CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 19092277HCID 19092277, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19092270HCID 19092270, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

0.5 g of palladium carbon (containing 10% by weight palladium) was added to a solution of 1.2 g (2.7 mmol) of 1-(4-nitrophenyl)-4-(4-phenyl-1-piperidinyl)piperidine (cf. Example 8) in 100 ml of methanol. Hydrogenation was continued until hydrogen uptake ceased, then the solids were filtered off and the solvent was removed under reduced pressure.

Workup

  1. filtrationthe solids were filtered off
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3fbb6811595a4c1a8c8a1164181806be
Source dataset
uspto-grants-1994_03
Patent number
US05296485

Reaction notes

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