HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-benzoyloxymethylene-6-methoxy-1-Tetralone → 6-Methoxy-2-methyl-1-tetralone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-benzoyloxymethylene-6-methoxy-1-Tetralone | HCID 53877965 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-Methoxy-2-methyl-1-tetralone | HCID 11116844 | 73.3% |
Reaction Steps
2-Benzoyloxymethylene-6-methoxy-1-tetralone (4.6 g, 0.015 mole) was hydrogenated over platinum oxide (160 mg) in isopropyl alcohol (150 mL) at 55 psi in a Parr hydrogenation apparatus. After about 90 minutes hydrogen uptake ceased and the reaction was stopped. The catalyst was removed by filtration and the solvents were removed in vacuo. The title compound (2.0 g, 0.011 mole, 70% yield) was obtained after purification by flash chromatography [gradient 10:1 to 5:1 EtOAc:Hexanes].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05296508 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-e893169f9b76468586780a54dde6d399 |
| Source note | uspto-grants-1994_03 |