反应详情

A mixture of 2-bromomethyl-4-tert-butylthiazole (3.4 g), 2-hydroxy-5-methoxybenzaldehyde (2.21 g) and potassium carbonate (2.0 g) in acetone (25 ml) was stirred under reflux for 7 hours. After being filtered, the filtrate was concentrated under reduced pressure to give a crude residue. The residue was subjected to column chromatography on silica gel and eluted with a mixture of toluene and ethyl acetate. The fractions containing object compound were combined and concentrated under reduced pressure to give a syrup. The syrup was crystallized from n-hexane and filtered to give 4-tert-butyl-2-(2-formyl-4-methoxyphenoxymethyl)thiazole (3.23 g).

1. temperatureunder reflux for 7 hours
2. filtrationAfter being filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. customto give a crude residue
5. washeluted with a mixture of toluene and ethyl acetate
6. additionThe fractions containing object compound
7. concentrationconcentrated under reduced pressure
8. customto give a syrup
9. customThe syrup was crystallized from n-hexane
10. filtrationfiltered