反应详情

温度

140 °C

A mixture of 4-tert-butyl-2-(2-formyl-4-methoxyphenoxymethyl)thiazole (3.23 g) and acetic anhydride (3.2 ml) in xylene (30 ml) was stirred at 140° C. for 14 hours. After being cooled, the resulting mixture was concentrated to give a syrup. The syrup was subjected to column chromatography on silica gel and eluted with toluene. The fractions containing object compound were combined and concentrated under reduced pressure to give 4-tert-butyl-2-(5-methoxybenzofuran-2-yl)thiazole (2.40 g).

1. temperatureAfter being cooled
2. concentrationthe resulting mixture was concentrated
3. customto give a syrup
4. washeluted with toluene
5. additionThe fractions containing object compound
6. concentrationconcentrated under reduced pressure