反应详情

温度

130 °C

A mixture of 4-tert-butyl-2-(2,4-diformylphenoxymethyl)thiazole (0.95 g) and acetic anhydride (12.9 ml) in dried xylene (100 ml) was stirred at 130° C. for 27 hours. After being cooled, the resulting mixture was concentrated in reduced pressure to give a residue. The residue was crystallized with diisopropyl ether. The resulting crystals were collected by filtration and washed with diisopropyl ether to give 4-tert-butyl-2-(5-formylbenzofuran-2-yl)thiazole (11.01 g).

1. temperatureAfter being cooled
2. concentrationthe resulting mixture was concentrated in reduced pressure
3. customto give a residue
4. customThe residue was crystallized with diisopropyl ether
5. filtrationThe resulting crystals were collected by filtration
6. washwashed with diisopropyl ether