反应详情

To a cooled solution of 4-tert-butyl-2-(5-methoxybenzofuran-2-yl)thiazole (1.0 g) in dichloromethane (10 ml), 1M solution of boron tribromide in dichloromethane (7 ml) was added dropwise at 5° C. After being stirred for 3 hours, the resulting solution was poured into a mixture of ice and aqueous sodium hydrogen carbonate. The resulting precipitates were collected by filtration and dissolved in a mixture of tetrahydrofuran and water. The solution was concentrated to give crystals of 4-tert-butyl-2-(5-hydroxybenzofuran-2-yl)thiazole (0.91 g).

1. customThe resulting precipitates
2. filtrationwere collected by filtration
3. dissolutiondissolved in a mixture of tetrahydrofuran and water
4. concentrationThe solution was concentrated