反应详情

A mixture of 4-tert-butyl-2-[5-(2-chloromethylphenylmethoxy)benzofuran-2-yl]thiazole (0.8 g), potassium cyanide (0.25 g) and Adogen 464 ((Aldrich phase transfer) one drop) in a mixture of toluene (8 ml) and water (8 ml) was stirred under reflux for 4 hours. After being cooled, the organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in reduced pressure. The resulting residue was subjected to column chromatography on silica gel and eluted with toluene. The fractions containing object compound were combined and concentrated under reduced pressure to give an oil of 4-tert-butyl-2-[5-(2-cyanomethylphenylmethoxy)benzofuran-2-yl]thiazole (0.67 g).

1. temperatureunder reflux for 4 hours
2. temperatureAfter being cooled
3. customthe organic layer was separated
4. washwashed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in reduced pressure
7. washeluted with toluene
8. additionThe fractions containing object compound
9. concentrationconcentrated under reduced pressure