反应详情

A mixture of 4-tert-butyl-2-(5-hydroxymethylbenzofuran-2-yl)thiazole (2.82 g) and thionyl chloride (1.4 ml) in dichloromethane (30 ml) was stirred under reflux for 1 hour. After being cooled, the resulting mixture was adjusted to pH 7 with aqueous sodium hydrogen carbonate. The organic layer was separated, washed with brine, dried over magnesium sulfate, concentrated under reduced pressure to give crystals of 4-tert-butyl-2-(5-chloromethylbenzofuran-2-yl)thiazole (2.93 g).

1. temperatureunder reflux for 1 hour
2. temperatureAfter being cooled
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure