反应详情

To a cooled solution of 2-(5-methoxybenzofuran-2-yl)-4,5,6,7-tetrahydro-8H-thiazolo[5,4-b]azepine (1.3 g) and pyridine (0.65 ml) in N,N-dimethylformamide (20 ml), a solution of acetyl chloride (0.41 g) in dichloromethane (2 ml) was added dropwise below 10° C. After being stirred for 2 hours, the resulting mixture was poured into brine and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give a syrup, which was crystallized from ethanol and collected by filtration to give 8-acetyl-2-(5-methoxybenzofuran-2-yl) 4,5,6,7-tetrahydro-8H-thiazolo[5,4-b]azepine (1.07 g).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customto give a syrup, which
6. customwas crystallized from ethanol
7. filtrationcollected by filtration