反应详情

A mixture of 4-tert-butyl-2-(5-formylbenzofuran-2-yl)thiazole (4.46 g), hydroxylamine hydrochloride (3.96 g) and sodium acetate anhydrous (5.0 g) in acetic acid (40 ml) was stirred at ambient temperature for 3 hours. Subsequently, acetic anhydride (13 ml) was added to the mixture. After being stirred for 30 minutes at the same temperature, the reaction mixture was stirred at 120° C. for 2 hours. After being cooled, the mixture was poured into water, followed by collecting by filtration. The precipitates were washed with water and air-dried at ambient temperature. The crude products were washed with petroleum ether to give 4-tert-butyl-2-(5-cyanobenzofuran-2-yl)thiazole (4.44 g).

1. stirringAfter being stirred for 30 minutes at the same temperature
2. stirringthe reaction mixture was stirred at 120° C. for 2 hours
3. temperatureAfter being cooled
4. filtrationby collecting by filtration
5. washThe precipitates were washed with water
6. customair-dried at ambient temperature
7. washThe crude products were washed with petroleum ether