反应详情

A mixture of methoxyacetic acid (360 g, 4 mol) and acetic anhydride (409 g, 4 mol) was heated with stirring in a 2 L 3-neck flask equipped with a bubble-plate distillation column and a fraction cutter. A mixture of acetic acid and acetic acid anhydride was distilled at atmospheric pressure until the internal temperature reached 164° C. The pressure was reduced and the product was collected at 65°-71° C. at 0.2 mmHg to give 229 g (71%) of pure title compound. A total of 34.8 kg of methoxyacetic acid was processed to give 26.1 kg (83%) of the anhydride (I).

1. temperaturewas heated
2. customequipped with a bubble-plate distillation column
3. distillationwas distilled at atmospheric pressure until the internal temperature
4. customreached 164° C
5. customthe product was collected at 65°-71° C. at 0.2 mmHg