Hydrochloric Acid → HCID 19093049, compound

Participants

Reaction Steps

40 ml of n-butanol and then 5.1 ml of concentrated hydrochloric acid were added to 2.96 g of n-butyl 5-acetyl-3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (Compound No. 18) obtained in Example 2. The resultant mixture was heated in a steam bath for 2 hours. The solvent was distilled off. 20° ml of acetonitrile was added to the reaction mixture and the crystals thus formed were taken by filtration to obtain 1.86 g (64%) of n-butyl 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate hydrochloride.

Provenance & Evidence