Hydrochloric Acid → HCID 19093049, compound

HRID 487726Notes

Reaction equation

HRID 487726 reaction equation
[ClH:1].C([N:5]1[CH2:10][CH2:9][C:8]2[S:11][C:12]([C:15]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:16])=[C:13]([NH2:14])[C:7]=2[CH2:6]1)(=O)C>C(O)CCC>[ClH:1].[NH2:14][C:13]1[C:7]2[CH2:6][NH:5][CH2:10][CH2:9][C:8]=2[S:11][C:12]=1[C:15]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11437923HCID 11437923, compound

Product 1

HCID 19093049HCID 19093049, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

40 ml of n-butanol and then 5.1 ml of concentrated hydrochloric acid were added to 2.96 g of n-butyl 5-acetyl-3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (Compound No. 18) obtained in Example 2. The resultant mixture was heated in a steam bath for 2 hours. The solvent was distilled off. 20° ml of acetonitrile was added to the reaction mixture and the crystals thus formed were taken by filtration to obtain 1.86 g (64%) of n-butyl 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate hydrochloride.

Workup

  1. custom18) obtained in Example 2
  2. distillationThe solvent was distilled off
  3. addition20° ml of acetonitrile was added to the reaction mixture
  4. customthe crystals thus formed
  5. filtrationwere taken by filtration

Sources & evidence

ORD record
ord-fdeaf3c32052472990cc735af0e521f1
Source dataset
uspto-grants-1994_03
Patent number
US05296603

Reaction notes

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