Dimethylamine, hydrochloride → HCID 70090841, compound

HRID 487743Notes

Reaction equation

[C:1]([CH2:4][NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([NH:17][C@H:18]([C:22]([N:24]2[CH2:41][CH2:40][CH2:39][C@H:25]2[C:26]([NH:28][CH:29]([CH:36]([CH3:38])[CH3:37])[C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])=[O:27])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:16])=[CH:10][CH:9]=1)=[O:7])([OH:3])=O.Cl.[CH3:43][NH:44][CH3:45]>>[CH3:43][N:44]([CH3:45])[C:1]([CH2:4][NH:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([NH:14][C:15]([NH:17][C@H:18]([C:22]([N:24]2[CH2:41][CH2:40][CH2:39][C@H:25]2[C:26]([NH:28][CH:29]([CH:36]([CH3:37])[CH3:38])[C:30](=[O:35])[C:31]([F:34])([F:32])[F:33])=[O:27])=[O:23])[CH:19]([CH3:20])[CH3:21])=[O:16])=[CH:12][CH:13]=1)=[O:7])=[O:3]

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 70051906HCID 70051906, compound

Product 1

HCID 70090841HCID 70090841, compoundYield 35.8%

Procedure

3(RS)-[[4-(Dimethylaminocarbonylmethylaminocarbonyl)phenylaminocarbonyl]-L-valyl-L-prolyl]amino-1,1,1-trifluoro-2-oxo-4-methylpentane (0.03 g) was prepared from 3(RS)-[[4-(carboxymethylaminocarbonyl)phenylaminocarbonyl]-L-valyl-L-prolyl]amino-1,1,1-trifluoro-2-oxo-4-methylpentane (0.08 g) and dimethylamine hydrochloride (0.012 g) by a similar method to that of Example 1.

Sources & evidence

ORD record: ord-d8584bba18eb4d6c8788d7f735920be8
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05296591

Reaction notes

Loading…