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HRID487745

反应详情

EQUATION

反应方程式

HRID 487745 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)c1c(C)oc(-c2ccccc2)[n+]1[O-].Cl
HCID19093060

1-(5-Methyl-3-oxo-2-phenyl-1,3lambda~5~-oxazol-4-yl)ethan-1-one--hydrogen chloride (1/1)

C12H12ClNO3

PRODUCTS

生成物

1
结构：CC(=O)c1nc(-c2ccccc2)oc1C
HCID12337849

1-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

C12H11NO2

收率 12.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Zn]
催化剂HCID23994

Zinc

Zn

结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Next, 100 g of 4-acetyl-5-methyl-2-phenyloxazole N-oxide hydrochloride was dissolved in 500 ml of glacial acetic acid and 100 g of zinc powder was added to the solution while cool stirring within a ice water bath. The separation was filtered after addition of 2 l of water and recrystalization was carried out by addition of methanol to produce 10 g of 4-acetyl-5-methyl-2-phenyloxazole (melting point; 74° to 76° C.).

WORKUP

后处理

  1. temperaturewhile cool
  2. customThe separation
  3. filtrationwas filtered
  4. additionafter addition of 2 l of water and recrystalization
  5. additionwas carried out by addition of methanol