4-acetyl-5-methyl-2-phenyloxazole N-oxide hydrochloride → 1-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

Participants

Reaction Steps

Next, 100 g of 4-acetyl-5-methyl-2-phenyloxazole N-oxide hydrochloride was dissolved in 500 ml of glacial acetic acid and 100 g of zinc powder was added to the solution while cool stirring within a ice water bath. The separation was filtered after addition of 2 l of water and recrystalization was carried out by addition of methanol to produce 10 g of 4-acetyl-5-methyl-2-phenyloxazole (melting point; 74° to 76° C.).

Provenance & Evidence