1-Chloro-2-(trifluoromethyl)benzene → HCID 14373143, compound

HRID 487750Notes

Reaction equation

HRID 487750 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[CH:12]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:52](=O)([O-])[O-:53].[Na+].[Na+].[C]=O>[Pd](Cl)Cl>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:52]([O:21][C:18]1[CH:19]=[CH:20][C:15]([CH:12]([CH3:14])[CH3:13])=[CH:16][CH:17]=1)=[O:53]

Participants

7

Reactant 5

HCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 74654-IsopropylphenolHCID 10340Sodium CarbonateHCID 821241,4-Bis(diphenylphosphino)butaneHCID 178418416HCID 178418416, compound2×

Product 1

HCID 14373143HCID 14373143, compound

Reagents, catalysts & solvents 1

HCID 24290Palladium ChlorideCatalyst

Procedure

In an autoclave made of a metal were placed 45.13 g of ortho-chlorobenzotrifluoride, 6.8 g of paraisopropylphenol, 88.5 mg of palladium chloride, 213 mg of 1,4-bisdiphenylphosphinobutane and 5.3 g of sodium carbonate. The air in the autoclave was replaced with carbon monoxide introduced thereinto in several times, after which carbon monoxide was further introduced to adjust its pressure therein to 30 kg/cm2. The internal temperature was adjusted to 190° C. on a salt bath and the reaction was carried out thereon with stirring for 4 hours.

Workup

  1. additionintroduced
  2. customThe internal temperature was adjusted to 190° C. on a salt bath

Sources & evidence

ORD record
ord-4ad03a75e8a14f449f4b03d6aff53f4b
Source dataset
uspto-grants-1994_03
Patent number
US05296601

Reaction notes

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