反应详情

温度

100 °C

Acetamide (10.0 g) and methyl 2-methoxymethylene-3-oxobutanoate (30.0 ml) were heated with stirring at 100° C. for 4 hours. On cooling the product was flash chromatographed on Merck silica 9385 using a 50/50 mixture of ether/hexane to give the title compound (18.5 g) m.p. 60°-62° C. (hexane/ether).

1. temperatureOn cooling the product
2. customchromatographed on Merck silica 9385 using
3. additiona 50/50 mixture of ether/hexane