Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | Methyl alpha-methoxymethyleneacetoacetate | HCID 54260517 | — |
| Product | HCID 178500808 | HCID 178500808 | — |
Reaction Steps
Acetamide (10.0 g) and methyl 2-methoxymethylene-3-oxobutanoate (30.0 ml) were heated with stirring at 100° C. for 4 hours. On cooling the product was flash chromatographed on Merck silica 9385 using a 50/50 mixture of ether/hexane to give the title compound (18.5 g) m.p. 60°-62° C. (hexane/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05296613 |
|---|
| Source dataset | uspto-grants-1994_03 |
|---|
| ORD ID | ord-47f7c28068304b65b12e93a440acd447 |
|---|
| Source note | uspto-grants-1994_03 |
|---|
