Trichloroacetyl chloride → HCID 178500843, compound

HRID 487759Notes

Reaction equation

HRID 487759 reaction equation
[NH2:1][CH:2]=[C:3]([C:8](=[O:10])[CH3:9])[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[Cl:18][C:19]([Cl:24])([Cl:23])[C:20](Cl)=[O:21]>C(Cl)Cl>[Cl:18][C:19]([Cl:24])([Cl:23])[C:20]([NH:1][CH:2]=[C:3]([C:8](=[O:10])[CH3:9])[C:4]([O:6][CH3:7])=[O:5])=[O:21]

Participants

5

Reactant 3

HCID 6420Trichloroacetyl chlorideHCID 8471TriethylamineHCID 178500805HCID 178500805, compound

Product 1

HCID 178500843HCID 178500843, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl 2-aminomethylene-3-oxobutanoate (1.4 g) in methylene chloride (20 ml) was treated with triethylamine (2.0 ml) and trichloroacetyl chloride (2.0 ml) while stirring at 20°-25° C. The mixture was stirred for 4 hours at 20° C. to give a solution of the title compound, which was used immediately to prepare the dihydropyran of Example 15 without isolation.

Workup

  1. stirringThe mixture was stirred for 4 hours at 20° C.

Sources & evidence

ORD record
ord-1587ce0d435e4c20a1fc506794bdb585
Source dataset
uspto-grants-1994_03
Patent number
US05296613

Reaction notes

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