Bromoacetyl bromide → 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1H-benzoimidazol-2-yl-methyl)-acetamide

HRID 48780Notes

Reaction equation

HRID 48780 reaction equation
[CH2:1]1[O:24][C:23]2[CH:22]=[CH:21][C:5]([CH2:6][CH:7]3[C:16]4[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=4[O:17][CH3:18])[CH2:10][CH2:9][NH:8]3)=[CH:4][C:3]=2[O:2]1.Br[CH2:26][C:27](Br)=[O:28].[NH2:30][CH2:31][C:32]1[NH:33][C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=1>>[CH2:1]1[O:24][C:23]2[CH:22]=[CH:21][C:5]([CH2:6][CH:7]3[C:16]4[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=4[O:17][CH3:18])[CH2:10][CH2:9][N:8]3[CH2:26][C:27]([NH:30][CH2:31][C:32]3[NH:33][C:34]4[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=4[N:36]=3)=[O:28])=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 3

HCID 61147Bromoacetyl bromideHCID 1458201H-Benzimidazole-2-methanamineHCID 227425451-(3,4-Methylenedioxy-benzyl)5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 227427452-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1H-benzoimidazol-2-yl-methyl)-acetamide

Procedure

prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-(aminomethyl)-benzimidazole

Sources & evidence

ORD record
ord-1845f7624a3a44c98e0c4f25cbf48824
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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