反应详情

A mixture of 2-(4-bromophenyl)acetic acid (50 g. 0.23 mol), benzyl alcohol (26 mL, 0.25 mol) and p-toluenesulfonic acid (0.3 g) in 200 ml toluene were heated at reflux with the azeotropic removal of water (15 h). The yellow solution was washed with water (250 mL). saturated aqueous sodium bicarbonate (250 mL) and then dried (MgSO4). Concentration provided a light yellow solid that was recrystallized from cold hexanes to give benzyl 2-(4-bromophenyl)acetate (48.5 g, 0.16 mol) in 69% yield, mp. 47.5°-48° C.

1. temperaturewere heated
2. washThe yellow solution was washed with water (250 mL)
3. dry with materialsaturated aqueous sodium bicarbonate (250 mL) and then dried (MgSO4)
4. concentrationConcentration
5. customprovided a light yellow solid
6. customthat was recrystallized from cold hexanes