HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 3-phenyl-2(R)-acetoxypropionic acid t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (R)-2-acetoxy-3-phenylpropanoic acid | HCID 11469837 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-phenyl-2(R)-acetoxypropionic acid t-butyl ester | HCID 53670319 | — |
Reaction Steps
Cool to -30° to -20° C., 3-phenyl-2(R)-acetoxypropionic acid (10.5 g) in CH2Cl2 (200 mL), add conc. H2SO4 (0.5 mL) and isobutylene (120 mL), seal the vessel, and stir at room temperature for 2 days. Vent the vessel, pour the reaction mixture into NaHCO3 solution, and extract with CH2Cl2. Dry the CH2Cl2 extract (MgSO4), then concentrate in vacuo to give 3-phenyl-2(R)-acetoxypropionic acid t-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05298492 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-910d21198aff4873b432f9205abfbbde |
| Source note | uspto-grants-1994_03 |