反应详情

Cool to -30° to -20° C., 3-phenyl-2(R)-acetoxypropionic acid (10.5 g) in CH2Cl2 (200 mL), add conc. H2SO4 (0.5 mL) and isobutylene (120 mL), seal the vessel, and stir at room temperature for 2 days. Vent the vessel, pour the reaction mixture into NaHCO3 solution, and extract with CH2Cl2. Dry the CH2Cl2 extract (MgSO4), then concentrate in vacuo to give 3-phenyl-2(R)-acetoxypropionic acid t-butyl ester.

1. temperatureCool to -30° to -20° C.
2. customseal the vessel
3. extractionextract with CH2Cl2
4. dry with materialDry the CH2Cl2
5. extractionextract (MgSO4)
6. concentrationconcentrate in vacuo