HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 4'-Fluoro-4-iodobutyrophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4'-Fluoro-4-iodobutyrophenone | HCID 3016232 | 96.2% |
Reaction Steps
20 g of 1-chloro-3-(p-fluorophenylcarbonyl)propane dissolved in 100 cm3 of methyl ethyl ketone are refluxed for 24 hours in the presence of 18.5 g of sodium iodide. After treatment, 28 g of the desired compound are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05298503 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-66ac03923542464c8a76255567268463 |
| Source note | uspto-grants-1994_03 |