HRID487869

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5238

Sodium Iodide

INa

HCID19750

4-Chloro-4'-fluorobutyrophenone

C10H10ClFO

PRODUCTS

生成物

HCID3016232

4'-Fluoro-4-iodobutyrophenone

C10H10FIO

收率 96.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

20 g of 1-chloro-3-(p-fluorophenylcarbonyl)propane dissolved in 100 cm3 of methyl ethyl ketone are refluxed for 24 hours in the presence of 18.5 g of sodium iodide. After treatment, 28 g of the desired compound are isolated.