Sodium Iodide → 4'-Fluoro-4-iodobutyrophenone

HRID 487869Notes

Reaction equation

HRID 487869 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].[I-:14].[Na+]>C(C(C)=O)C>[I:14][CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 197503-(4-Fluorobenzoyl)propyl chloride

Product 1

HCID 30162324'-Fluoro-4-iodobutyrophenoneYield 96.2%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

20 g of 1-chloro-3-(p-fluorophenylcarbonyl)propane dissolved in 100 cm3 of methyl ethyl ketone are refluxed for 24 hours in the presence of 18.5 g of sodium iodide. After treatment, 28 g of the desired compound are isolated.

Sources & evidence

ORD record
ord-66ac03923542464c8a76255567268463
Source dataset
uspto-grants-1994_03
Patent number
US05298503

Reaction notes

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